Research and Clinical Trials

Mayo Clinic doctors discuss the role clinical trials — research studies that test new treatments and other interventions — play in cancer care.

The presence of a specific genetic mutation — KRAS circulating tumor DNA (ctDNA) — strongly indicates a higher risk of spread and worse survival rates for people with pancreatic cancer.

The team identified specific proteins — fibronectin and smooth muscle actin — associated with resistance to immunotherapy treatment in colorectal cancer tissues.

Drs. Vincent Rajkumar and Rafael Fonseca explain what smoldering multiple myeloma is and how treating it could potentially delay or prevent multiple myeloma.

Researchers have discovered a new role that a protein known as NKG7 plays in regulating cell resistance and fighting tumors in certain types of cancer.

Mayo Clinic pancreatic cancer experts highlight the importance of early diagnosis and the role of artificial intelligence in transforming patient outcomes.

Dr. Keith Knutson explains how the development of personalized lung cancer vaccines is giving patients hope.

Dr. Allison Rosenthal, a Mayo Clinic hematologist specializing in lymphoma, answered questions about the disease in a Reddit AMA.

Dr. Richard Vile, a Mayo Clinic immunologist and cancer researcher, explains how CAR-T cell therapy works, including the benefits, risks and realities of treatment.

Drs. Haidong Dong and Svetomir Markovic, Mayo Clinic immunologists, discuss how immunotherapy works, its benefits and risks, and why they’re excited about its future.